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What is a known delayed sign of acetaminophen poisoning?

Increased blood pressure

Confusion or disorientation

Jaundice

In cases of acetaminophen poisoning, one of the known delayed signs is jaundice. Jaundice indicates a yellowing of the skin and the whites of the eyes, which occurs due to the accumulation of bilirubin resulting from liver damage. Acetaminophen is metabolized in the liver, and an overdose can lead to hepatotoxicity, where the liver is unable to process the drug effectively, resulting in cellular damage and impaired function. As the liver becomes more damaged, symptoms such as jaundice can manifest, typically 24 to 72 hours after the initial toxic dose. Recognizing jaundice as a delayed sign is crucial for timely intervention and treatment of acetaminophen toxicity.

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